Centre for Personalised Medicine Managing Infectious Complications in Immune Deficiency (PERSIMUNE)

Information

Center leader:

Professor Jens Lundgren

Period:

2015 - 2021

Application round:

8th Round

Host institution:

Rigshospitalet

Grant:

60.0 mil. DKK

Follow us on social media:

The multidisciplinary centre at Rigshospitalet works from the hypothesis that across patient with impaired immune function, there is a common pattern of undiscovered risk factors explaining the variation in risk of infectious complications.

Initially we aim at understanding
the mechanisms explaining the variation in risk using a diverse set of methodologies, including pattern recognition from big data from routine care, studies of host and microbial genetics, imaging, and immunological characterization.

The discovery phase will likely identify novel mechanisms of host defence, which will be used to characterize groups of immunocompromised patients and identify clusters of factors associated with comparable types of infectious complications.

From this, we will formulate a series of immunodeficiency indices encapsulating the variation in risk of infectious complications. The indices will be validated and used to personalise interventions aimed at reducing infectious complications.

Watch videos from PERSIMUNE here

Latest news

PERSIMUNE investigates how patients with septic shock reacts to induced hypotermia

Read more

Precision medicine and bioinformatics with 320 mph: When data sharing increases the understanding of diseases

Read more