Center for Chromosome Stability (CCS)

Information

Center leader:

Professor Ian D. Hickson

Period:

2015 - 2025

Application round:

8th Round

Host institution(s)

University of Copenhagen

Grant:

110M DKK

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The maintenance of chromosome stability is of paramount importance for the successful propagation of all species. A breakdown in chromosome maintenance is an underlying feature of several debilitating disorders in humans ranging from birth defects and some forms of neurodegeneration to cancer.

In the Center for Chromosome Stability, we investigate the molecular causes and consequences of defects in chromosome maintenance. We have a particular emphasis on regions of the human genome that are intrinsically unstable due to their atypical structure disrupting successive rounds of DNA replication.

We combine molecular/cell biological techniques with analysis of model organisms such as yeast and mice to define precisely how these ubiquitous ‘enemies within’ the genome undermine the integrity of chromosomes, and how their instability is normally counteracted.

Our ultimate aim is to develop new preventative or therapeutic strategies for combating human diseases associated with chromosomal instability.

Highlights

Highlights 2020

Highlights 2019

Highlights 2018

Latest news

Press release from CCS: Researchers identify new genes linked to longer reproductive lifespan in women

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Other April News in Brief

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Eva Hoffmann from CCS is a new member of EMBO

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