Center for Autophagy, Recycling and Disease (CARD)

Information

Center leader:

Head of Research, Professor Marja Jäättelä

Period:

2015-2020

Application round:

8th Round

Host institution(s)

The Danish Cancer Society

Grant:

50.0M DKK

Cellular homeostasis is governed by integrated activities of energy-supplying organelles, macromoleculeproducing factories and recycling pathways. As in our modern society, also in our cells, power supply, activity and waste disposal need to be kept in equilibrium and
respond to immediate internal and external demands.

Autophagy, a process of self-eating, is a key actor in this process. It ensures rapid removal of toxic materials as well as damaged or superfluous macromolecules and organelles through lysosomal degradation and recycling, thereby providing means for waste disposal
and molecules for energy production and renovation.

It also participates in essential cell-fate decisions concerning survival, malignant transformation and differentiation.

CARD will combine complementary expertise at the Danish Cancer Society Research Center to elucidate the orchestration of cellular energy balance, damage control, recycling and autophagy with focus on autophagy regulating pathways and their crosstalk with other cellular processes.

Annual highlights

Highlights 2019

Highlights 2018

Latest news

The Anders Jahre Medical Prize 2020 is split between a former DNRF head of center and current group leader at CARD

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CARD will test a well-known drug in the fight against coronavirus

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CARD researchers rewrite the textbooks; discover hidden mechanism in cell division

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