 | DNRF Chair: Vijay Tiwari, Professor Period: October 2023 - September 2026 Host institution: University of Southern Denmark | |
Gene Regulatory Mechanisms Underlying Neural Fate Decisions and Its Disruption in Neurological Disorders Mammalian brain development involves highly complex and organized sets of events. Building on past experiences
and using a highly multidisciplinary approach, which combines neurobiology, epigenetics, and computational biology, we currently aim to comprehensively reveal gene regulatory circuitry that defines distinct subpopulations of the cortex and how these subpopulations communicate with each other and con- tribute to brain function. Finally, we aim to decode how disruption of these layers of regulation predisposes for certain neurological disorders and whether their targeting can provide novel therapeutic avenues for these challenging conditions.
and using a highly multidisciplinary approach, which combines neurobiology, epigenetics, and computational biology, we currently aim to comprehensively reveal gene regulatory circuitry that defines distinct subpopulations of the cortex and how these subpopulations communicate with each other and con- tribute to brain function. Finally, we aim to decode how disruption of these layers of regulation predisposes for certain neurological disorders and whether their targeting can provide novel therapeutic avenues for these challenging conditions.
