Proteins suppress useless gene activity in human cells

A new study shows how our cells sort the wheat from the chaff in a tangle of useful and useless gene molecules. In collaboration with international research groups, a Danish research team from Aarhus University has now found a mechanism that helps the cells prevent accumulation of the many useless RNA molecules being constantly produced by runaway gene activity in our cells. These findings contribute to a new understanding of our genes and may eventually help our understanding of gene activity in stem cells and cancer.

The work was carried out by Postdoctoral Fellows Peter Refsing Andersen and Michal Domanski and other members of the Torben Heick Jensen laboratory at the Danish National Research Foundation’s Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology and Genetics, Aarhus University. The work was done in collaboration with research groups from Odense, Montpellier, Stockholm, Dresden and New York. The new results have just been published online in the journal Nature Structural & Molecular Biology.

Read more on Aarhus University’s homepage

Read the article in Nature Online