Length matters in gene expression

Human genomes harbour thousands of genes, each of which gives rise to proteins when it is active. But which inherent features of a gene determine its activity?

Postdoctoral Scholar Pia Kjølhede Andersen and Senior Researcher Søren Lykke-Andersen from Centre for mRNP Biogenesis and Metabolism have now found that the distance between the gene start, termed the ‘promoter’, and the gene end, the ‘terminator’, is crucial for the activity of a protein-coding gene. If the distance is too short, the gene is transcriptionally repressed and the output is therefore severely decreased. This finding outlines a completely new functional interplay between gene ends.

Read the coverage at Aahus University’s website



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